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Impaired glucose metabolism Neurons primarily rely on glucose for energy production via oxidative phosphorylation (OXPHOS) in healthy brains

Most disease-causing mutations in these proteins occur in low-complexity domains mediating liquid-liquid phase separation to alter protein conformation, which promotes the aggregation and disrupts RNA regulation while also generating additional toxicity

Compounded semaglutide with vitamin B12 is available in the market but has not been approved by the Food and Drug Administration (FDA)

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