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The primary site of GPS metabolism is the liver, where cytochrome P450 enzymes play a significant role in its biotransformation, resulting in the generation of diverse metabolites ( 6 Toxicity and safety Research into the acute toxicity of GPS in animal models, including mice and rats, indicates that GPS exhibits a relatively low level of acute toxicity

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Overall, low return rates for TOC limited the data we have, and the small proportion of those who were prescribed a single 84-dose fill limit the power of the data we collected

The sequences of the specific primers were shown in Supplementary Table S5

However, glutathionylation is reversible through the release of GSH from cysteine residues in target proteins by thioredoxins and glutaredoxins, which are thiol oxidoreductases 138,142