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(2009) found that mutation of a Gpx to exchange the selenocysteine to cysteine at the catalytic site reduced the specific activity of the enzyme by two to three orders of magnitude

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Some studies suggest that individuals with low levels of B12 are more prone to developing age-related cognitive decline and that supplementation can slow down or even reverse certain symptoms of mental impairment

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Benowitz NL, Jacob P3, Mayan H, Denaro C (1995) Sympathomimetic effects of paraxanthine and caffeine in humans