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10.1007/s00432-020-03222-w

The search was performed in multiple databases, including PubMed, Web of Science, and Embase, and was supplemented by manual searches using Google Scholar to ensure completeness

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Chapter 2 in Textbook of Physiology, 2023

Collectively, mitochondria as the primary generators and the recipients of oxidative damage, implies a vicious cycle wherein impaired mitochondria produce increased amounts of ROS, in turn leading to a progressive accumulation of damage that culminates in the process of aging (Figure 1)