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The Importance of the Cortisol Awakening Response Cortisol is the major circulating hormone of the hypothalamic pituitary adrenal (HPA) axis, exerting its effects through the glucocorticoid receptor expressed in almost all human cells

Blood pressure decreases by an average of 5-10 mmHg systolic

If history or physical signs suggest dehydration, Reclast therapy should be withheld until normovolemic status has been achieved [see Adverse Reactions (6.2)]

Administration of GH to elderly healthy adults has generally been associated with predictable, albeit modest, effects on body composition and side effects in terms of fluid retention and modest insulin resistance (34)