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These pathways enhance glucose uptake and glycolysis through increased expression of glucose transporters and glycolytic enzymes

Cell 187, 40434060.e30

In summary, FGF21s anti-inflammatory actions likely arise from both direct suppression of proinflammatory signalling, by innate and possibly adaptive immune cell types as well as attenuation of immune-effector cell infiltration into the liver, and its indirect inhibition of pro-inflammatory signals released by injured hepatocytes

Pharmacological concentrations of ascorbate radiosensitize glioblastoma multiforme primary cells by increasing oxidative DNA damage and inhibiting G2/M arrest

While some variants showed wild-type affinities or nominal increases in KD-app (for example, FIXa-R318Y / R338E and FIXa-R318Y / R338E / R403E / E410N), several variants showed marked increases in functional affinity with more than increases