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Indeed, SLC7A11 expression can be potently induced upon deprivation of various amino acids, including cystine, and amino acid deprivation-induced SLC7A11 expression is largely mediated by ATF4 (Sato et al., 2004)

The use of new therapies in axSpA requires continuous and regular evaluation of their role in disease management in specific contexts

This system operates through several mechanisms, including direct scavenging of reactive species, metal chelation, and enzymatic processes that rapidly neutralise reactive molecules following their formation (126, 243, 256)

PLoS Comput Biol 8(1):e1002341 Ariel FD, Manavella PA, Dezar CA, Chan RL (2007) The true story of the HD-Zip family