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First, as a heterogeneous disease, VCI has many etiologies and can be categorized into various forms

This condition encompasses a spectrum of neurological dysfunctions, spanning asymptomatic neurocognitive impairment and mild neurocognitive disorder, to HIV-associated dementia, which results in severe cognitive deficits and memory loss (Saylor et al

beta blockers and alpha agonists have important systemic side effects that may be life-threatening

Folate enters OCM as tetrahydrofolate (THF) which acquires a carbon unit from serine in a B 6 -dependent reaction to form 5,10-methyleneTHF

C.BorgersG.EliaI.et al (2015)