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However, prolonged high dosing can sometimes lead to irritability or behavioral activation

Side effects of meth include tooth decay, difficulty sleeping, weight loss, sweating, mood swings, anxiety, depression, irritability, increased blood pressure, irregular heartbeat, psychosis, hallucinations, paranoia, inability to control thinking or motor skills, easily distracted, memory loss, violence or aggression and addiction

This occurs without the chromosomal instability associated with oncogenic telomerase activation

Notably, obesity disrupts both adipose NAD + homeostasis and sirtuin enzymatic function, leading to mitochondrial deficits and metabolic complications (411)