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Nature 622, 677678

Curr Drug Deliv [Internet]

Without treatment, it leads to permanent foot deformity and dramatically increased amputation risk

Pocai A, Lam TK, Obici S, Gutierrez-Juarez R, Muse ED, Arduini A, Rossetti L: Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats