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(11) Another interesting observation was the considerable improvement in brain edema, swelling in the brain tissue often caused by traumatic injuries

Imaging studies have demonstrated that chronic cocaine users often exhibit brain atrophy and reduced gray and white matter volumes, particularly in the limbic regions essential for emotional processing and reward (Rando et al., 2013)

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If orthostatic hypotension is suspected, take BP while patient is sitting, standing, and supine