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Microdose-Specific Considerations Lower starting dose may reduce the severity or frequency of GI side effects during initiation All boxed warnings and contraindications still apply regardless of dose Your provider will titrate the dose upward based on tolerance and response References Tirzepatide ODT Pills (Compounded) Tirzepatide Oral Dissolving Tablets (ODT) provide a needle-free oral form of the same dual GIP/GLP-1 receptor agonist as injectable tirzepatide

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To test this hypothesis, we used ITC to measure binding between Axin LIR and a synthetic 43mer peptide spanning Axin LIRup (A308-Q351) with or without phosphorylation of the S1 triplet (Fig