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Treatments such as CD52 monoclonal antibodies, mesenchymal stem cells, and specific compounds like Oridonin and KGF-2 have demonstrated efficacy in reducing T cell apoptosis and modulating inflammatory pathways, while other approaches focus on directly influencing intestinal epithelial cells to mitigate CD symptoms

Notably, the cytotoxicity of both ZIO-101 and ATO was cell cycle-dependent with the highest cytotoxicities in the S and G2/M phases and the lowest in the G1 and S phases [115]

two-tailed unpaired t -test

Compounds such as corilagin and cyanidin-3-O-glucoside stimulate Parkin-mediated mitophagy, mitigating NAFLD by inhibiting hepatic oxidative stress, NLRP3 inflammasomes, steatosis, and improving systemic glucose metabolism (Zhang et al., 2019

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