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This observation can be explained by a certain time period needed by dupilumab to fully exert its effect in BP

Yu T, Van der Jeught K, Zhu H, Zhou Z,Sharma S, Liu S, Eyvani H,So KM,Singh N, Wang J, Sandusky GE,Liu Y

Mozafar A

Some showed the disruption of the blood-testis barrier (141) in obesity, while some suggested that the duration have an unfavorable impact on male fertility (142, 143)