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Furthermore, HIF-1 promotes glycolysis while inhibiting mitochondrial oxidative phosphorylation, indirectly destabilizing the electron transport chain and further enhancing ROS accumulation (Liang et al., 2021), thereby further accelerating ferroptosis progression

NFPS N-[3-(4-fluorophenyl)3-(4-phenylphenoxy)propyl] sarcosine (NFPS), also known as ALX-5407, is a sarcosine-based GlyT1 inhibitor

[Google Scholar] [82].Hearn MTW, Smith PK, Mallia AK, Hermanson GT, Preparative and analytical applications of CDI-mediated affinity chromatography, in: Chaiken IM, Wilchek M, Parikh I (Eds.), Affinity Chromatography and Biological Recognition, 1st ed., Academic Press, Orlando, FL, 1983: pp

For people with T2D, a phase 2 trial showed that 12 weeks of efinopegdutide achieve up to 7.9% WL (compared to 0.7% WL with placebo) without actual improvement in HbA1c [78]

Leucovorin, also known as folinic acid, is a derivative of vitamin B9