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Cournoyer, J

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Extending from the physical and biochemical properties of the engineered NPPC-derived exosomes, we further develop an injectable hydrogel filler based on clinically-tested ECM analogs including hyaluronic acid (HA) and oxidized chondroitin sulfate (OCS) as the exosome delivery platform (HACS@CPP-miR-Exo) for post-discectomy management, which is not only well tolerated in the operation-induced NP cavity but also enables sustainable release of the engineered exosomes to mediate continuous ferroptosis reversal in NPCs (Fig