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Kross and Scheer, 1991), and the ClO 2 prodrug NaClO 2 has also been approved as an ALS orphan drug by the European medicines agency (EMA) (EU/3/13/1139, 2024), and has demonstrated efficacy in a subset of ALS patients administered NaClO 2 intravenously in a Phase 2B clinical trial, notably reducing LPS levels in the blood which would suggest antimicrobial efficacy (Zhang et al., 2022)

2020;261:120347 Khan MM, Torchilin VP

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