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routine use in replete patients has limited evidence

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Evidence-based supplement companion for KPV (Lysine-Proline-Valine): kPV is the three-amino-acid tail of alpha-MSH: it keeps the parent hormone's anti-inflammatory power, drops the pigmentation, and targets inflamed tissue through the PepT1 transporter

Notably, several of the pro-inflammatory cytokines known to upregulate CD38 expression, including IL-6, interferons, TGF-, as well as SASP, are also implicated in SSc 2