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The relative change in current caused by hybridization () was calculated by dividing the difference between the peak currents before (I ss ) and after (I ds ) hybridization by the current before hybridization (I ss ) using equation (1): The relative current increase after hybridization with target diminished from 14.6% to 3.3% and 0.3% after hybridization with single base pair mismatch and noncomplementary sequences respectively

doi: 10.1530/eje.0.1480325

GLP-1 RAs produced greater BMI reductions than metformin in head-to-head comparisons

We anticipate that this synthetic design will pave the way for the synthesis of currently inaccessible targets due to its excellent efficiency and simplicity

The prasinezumab trial (PASADENA), however, showed significantly slower decline in MDS-UPDRS part III scores (a key secondary endpoint) at week 52 as well as consistent results in exploratory digital motor measures [207]