melatonin glutathione peroxidase Alternative modes of action in target cells. Melatonin can This figure illustrates the actions

Manganese upregulates cellular prion protein and contributes to altered stabilization and proteolysis: relevance to role of metals in pathogenesis of prion disease

The caveat of the research is that glutamate act on its different receptors that might be expressed on the human melanoma cells used in the study, therefore, the mentioned observation is a net effect from different receptor activation

And then free radicals

Structural analysis using AlphaFold multimer CBS sequences were obtained from UniProt 63 , and their sequences aligned using Clustal Omega 64

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