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Their effectiveness is largely attributed to the significant upregulation of surface CD38, achieved by degrading Ikaros and Aiolos

in obese murine models exposed to the peptide for approximately three weeks suggested that any gain in overall mass was estimated to be cut in half compared to placebo controls

Figure 4 Macrophages are the key mediators by which monoclonal antibodies to play a therapeutic role, and antibodies targeting CD38 will also affect macrophage function ( Summary and Prospects CD38 has dual functions, acting as an extracellular enzyme and a surface receptor

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