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There is a clear need for parallel in vitro and in vivo studies in the short term in order to untangle the pathways and mechanisms involved, with the in vivo studies in particular providing important insights into the final biomolecule coronas following in vivo biodistribution and/or during bioclearance [143]

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J Pediatr 124:229233 Larsson A, Anderson ME (2001) Glutathione synthetase deficiency and other disorders of the gamma-glutamyl cycle