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When referring to antioxidant effects, it is equally appropriate to address natural and synthetic antioxidants, such as: retinol (vitamin A), ascorbic acid (vitamin C), -tocopherol (vitamin E) and its water-soluble derivatives trolox, N-acetylcysteine (NAC), uric acid, some of the target molecules of Nrf2 (GSH, CoQ)

Escribano-Ferrer, E., Queralt Regu, J., Garcia-Sala, X., Boix Montans, A., & Lamuela-Raventos, R

In -thal, elevated EPO stimulates erythroblasts to secrete erythroferrone, which hinders Hepcidin through the BMP-SMAD pathway, leading to iron overload

Figure 3 Construction of GSTM1 and GSTT1 knockout mice To further investigate the mechanism by which GSTM1 and GSTT1 are involved in the pathogenesis of acute kidney injury (AKI), we successfully constructed mice with GSTM1 and GSTT1 knockout (GSTM1-KO and GSTT1-KO) using CRISPR-Cas9 technology