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Subsequently, Nrf2 accumulates and translocates to the nucleus, where it binds to the Antioxidant Response Element (ARE), initiating the transcription of a battery of cytoprotective genes responsible for counteracting inflammation and oxidative stress

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The entorhinal cortex is the primary brain region to be affected in Alzheimer's disease 21

Although the proposed vicious cycle remains a working hypothesis requiring further validation, understanding this interplay may help identify novel biomarkers, stratify patients by metabolic phenotype, and guide precision therapies for HF

The cancer can also invade nerves, blood vessels, and lymphatics within the pancreas