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Zhou YF, Zhu YW, Wang YW, Liang XY, Jiang QY, Wu DD (2025) Diallyl disulfide in oncotherapy: molecular mechanisms and therapeutic potentials

This pharmacokinetic profile contrasts sharply with that of small-molecule CYP3A4 substrates or inhibitors

However, not only does p62 prevent NRF2 binding to KEAP1, it induces autophagic degradation of KEAP1, resulting in a positive feedback loop of NRF2 activation [82]