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In addition, mitochondrial dysfunction in stromal cells is the key causal factor triggering fibrosis-induced ovarian decline, and metformins reversal of ovarian fibrosis converges on related mitochondrial metabolic pathways that are upstream of oxidative stress and inflammation (Umehara et al., 2022)

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Activation of Integrin 5 Mediated by Flow Requires its Translocation to Membrane Lipid Rafts in Vascular Endothelial Cells

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