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These promising results led to a long-term follow-up study of 4 weeks with once daily dosing in diabetic rats, which further showed that insulin-loaded CMCD-g-CMC hydrogels were effective in treating the symptoms of polyphagia, polydipsia, polyuria, and weight loss, as well as in improving fasting blood glucose levels and oral glucose tolerance test outcomes [56]

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Adrenergic regulation of cardiac contractility does not involve phosphorylation of the cardiac ryanodine receptor at serine 2808