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Apart from female and male infertility (41, 42), Se deficiency was connected to heart disease (possibly fatal congestive dilated cardiomyopathy, including endemic Keshan disease), musculoskeletal and neuromuscular disorders (e.g., KashinBeck disease), thyroid function dysfunction, disrupted immune function, poor response to acute and chronic infections (including COVID-19, Coxsackie, influenza, and HIV viral infections), chronic inflammation, cancer (including colonic, gastric, pulmonary, and prostate carcinoma), and other disorders (40, 4348)

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The glutamine transporter protein family (SLC) is localised on the cell membrane and enables cancer cells to take up sufficient Gln from the outside to meet their growth and metabolic requirements

Palasciano G, et al

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