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doi:10.1126/science.1072994 CrossRef Howes MJR, Perry NSL

Studies in fast-aging XpdTTD/TTD mouse models reveal comprehensive rejuvenation effects following FOXO4-DRI administration

The glutamate-induced persistent depolarization affects mitochondrial membrane polarization, impairing mitochondrial function and energy metabolism (see section Oxidative stress and redox imbalance in the CNS, and [91])

Conclusions To overcome long-standing challenges associated with off-target radiation damage resulting in life-long dry mouth and poor quality of life, we sought to leverage our salivary gland tissue chip technology to identify candidate radioprotective drugs 19