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Our findings thus suggest that oxidative stress-mediated lysosomal dysfunction likely plays a critical role in the pathogenesis of HAND in cART-treated HIV-infected individuals and that antioxidant-mediated mitigation of oxidative stress could be considered as an adjunctive therapeutic strategy for ameliorating/dampening some of the neurological complications of HAND

This steady-state assumption induces relations between the rate constants and initial concentrations that, in principle, allow to compute initial concentrations from rate constants

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However, it has not been proven universally more effective or clinically superior to reduced glutathione