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OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies

The free aldehyde in the open-chain form of the alkenal adduct can react with a second lysine, histidine, or cysteine and then can act as a heterobifunctional cross-linking reagent

In addition, the choice of an affinity can also rely on the size: small tags are useful for protein detection and antibody production, as they are not immunogenic as large tags (Terpe, 2003)