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Melatonin administration to aged mice also demonstrated the therapeutic utility of this compound in the treatment of age-related cardiac sarcopenia, since it preserved the normal cardiomyocyte structure and restored their number, as well as to reducing -myosin heavy chain expression (a marker of cardiac hypertrophy) in these animals

Gene knockout in EpiSCs EpiSC knockout lines were created using the CRISPR-Cas system

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