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14.4 Treatment and Prevention of Glucocorticoid-Induced Osteoporosis The efficacy and safety of Reclast to prevent and treat glucocorticoid-induced osteoporosis (GIO) was assessed in a randomized, multicenter, double-blind, stratified, active controlled study of 833 men and women aged 18 to 85 years (mean age of 54.4 years) treated with greater than or equal to 7.5 mg/day oral prednisone (or equivalent)

ChIP-qPCR assays performed using an anti-BRD4 antibody revealed a markedly higher enrichment of BRD4 at PGK1 and VIM promoters in GFP-ASXL1 1-645 -WT expressing cells compared to the enrichment of BRD4 in GFP-ASXL1 1-645 -I574D expressing cells, indicating the ASXL1 EBM -dependent recruitment of BRD4 (Fig

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