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However, for othersparticularly those with a more severe deficiency or underlying health conditionsit may take up to a week or even several weeks to experience significant changes

Can that happen

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Instead of taking B12 supplements, it is possible to get sufficient amounts from B12-fortified foods, but we would have to eat three servings a day of foods each providing at least 85 percent of the Daily Value (on the Nutrition Facts label), with each serving eaten at least four to six hours after the last (the target is 2 mcg three times a day)

That quick response is one reason injections are often recommended for people with ongoing fatigue or confirmed deficiency