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doi: 10.1007/s00403-019-01972-3

Side-effect profiles do not significantly overlap

The practical difference for most people is minimal, though methylcobalamin skips the conversion step and may be preferable for individuals with certain genetic variations affecting B12 metabolism

Experts suggest that if a patients serum vitamin B12 level is between 150 to 399 pg/mL (111 to 294 pmol/L), the patients serum MMA levels should be checked to help confirm a diagnosis of vitamin B12 deficiency [7,9]