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2022;73(4):1359-1364 Nakatsuka K

doi: 10.1016/j.jaci.2007.08.028

Oxidation of these enzymes has been reported to lead to a reduction of their activities 33,35,62 , enabling diversion of carbon flux from glycolysis towards nucleotide and glutathione synthesis 62 : Slowing glycolysis down enables for glycolytic intermediates to be pushed towards serine synthesis and consequently folate cycle and/or trans-sulfuration pathway 63 to provide glycine and cysteine, the building blocks for glutathione production (Figs