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[PubMed: 18669592] 203

Creation of a claudin-2 binder and its tight junction-modulating activity in a human intestinal model

Vitamin B12 deficiency can lead to hematological, neurological diseases (Alzheimers), and possibly cardiovascular disease

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However, we did not observe significant differences in circulating IGF-1 levels with mAb treatment in older mice, though levels tended to be higher in mAb-treated females, but glucose homeostasis was not adversely affected in either sex, suggesting minimal disruption of the somatotropic axis in this older cohort of mice