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The elderly are at higher risk because their ability to produce intrinsic factor declines with age

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Ceylan et al

Further research has found that in intestinal epithelial cells with reduced or deficient GPx4, ACSL4 induces the release of interleukin 6 (IL6) and chemokine (C-X-C motif) ligand 1 (CXCL1) by regulating PUFA, especially Aa, leading to inflammation

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