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Its relevance to neuropathy is most direct in the metabolic neuropathies, particularly diabetic peripheral neuropathy, where impaired glucose metabolism, insulin resistance, and mitochondrial dysfunction all contribute to nerve damage

Acute liver failure from paracetamol toxicity has a high mortality rate of 30% if there is no liver transplantation available[89,90]

However, the pronounced irregularity of the spherical vesicles and tubules induced by the SNX1-SNX2a heterodimer hindered the application of iterative helical real-space reconstruction, making it impractical to obtain high-resolution structural information for the complex

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These systems are summarized here and their implications are discussed