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Causes and progression factors of liver inflammation Direct damage caused by alcohol metabolites Ethanol metabolism in the liver occurs through three primary pathways: the alcohol dehydrogenase (ADH) pathway in the hepatocyte cytosol, the cytochrome P450 2E1 (CYP2E1) pathway in the endoplasmic reticulum, and the catalase (CAT) pathway in peroxisomes [18]

516,517 Knockdown of METTL3 promotes the expression of FSP1 and SLC7A11, whereas METTL3 overexpression aggravates cystine deprivation- and erastin-induced ferroptosis in human aortic smooth muscle cells (HASMCs), suggesting that METTL3 may promote ferroptosis in HASMCs primarily by inhibiting FSP1 and SLC7A11 expression

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10.1016/j.ceb.2015.02.003 89 ShuklaP

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