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Upon activation, these pathways regulate glucose uptake, glycogen synthesis, and glycolysis

Right after GSH enters the catalytic site of PCS, a Gly residue is removed to form the Glu-Cys acyl-enzyme intermediate, and then a metal-GS 2 accepts the Glu-Cys unit to generate a PC 2 ((Glu-Cys) 2 -Gly) [6, 21, 54, 55]

These mutations map primarily at protomer/protomer interfaces within the pentamers, an observation supporting our hypothesis that they contribute to the formation of a stable capsid even in the absence of adequate concentrations of GSH