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The isolated fraction induced delta-wave (slow-wave) sleep when injected into recipient animals giving the peptide its name and initiated one of the most distinctive research trajectories in neuropeptide biology: a compound with a clearly demonstrated biological name-property, an exceptionally wide pharmacological activity profile, and nearly five decades later a receptor that remains formally uncharacterised

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Astrocyte-mediated regulation of CBF Perivascular astrocytes, located near synapses, are stimulated by neuronal activity, while their end-feet envelop blood vessels and communicate with SMCs and pericytes, which regulate CBF

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