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doi: 10.3389/fcell.2021.653815 131 LouveauA

During adaptive immunity, Lactobacillus, Clostridium, Bifidobacterium , and Enterococcus in the gut can reduce inflammatory responses by producing lipid metabolites and reducing tumor necrosis factor (TNF-), and inflammatory mediators interleukin-1(IL-1), interleukin-6 (IL-6), and interleukin-18(IL-18) (175178)

In particular, back in 1996 Przedborski and colleagues indicated that GSH peroxidase activity is reduced in a specific brain region affected in ALS, the precentral gyrus, suggesting that the observed deficit could be involved in the oxidative damage observed in sporadic ALS [102]