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Since vitamin B12 is primarily found in animal products, individuals following a plant-based diet may be at risk of deficiency

Psychiatry 122 , 509522 (1965)

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While there is now little doubt that a degenerative process operates not only in the later progressive phase of the disease, but also likely from the earliest stages of relapsing inflammatory presentations, what is fiercely debated is whether a primary autoimmune inflammation also drives the continuing CNS cytodegeneration and CNS atrophy (Sen et al., 2020