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40 There is insufficient evidence to suggest that B12 on its own is beneficial in depression

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The Myth of B12 as a Performance Enhancer The Mayo Clinic weighs in definitively on this topic: Some researchers have studied vitamin B-12 to find out if it can raise energy and endurance during exercise

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The reason why homocysteine is dangerous is because it damages cells and tissues of the arteries, triggers inflammatory reactions and enables cholesterol oxidation, which contributes to the build-up of atherosclerotic plaques the main culprits in cardiovascular disease (Kumar et al., 2017)