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456 However, we recommend caution against excessive elevation of BCAAs as BCAAs imbalance is associated with detrimental health consequences, including hyperphagia, metabolic disorders, cardiovascular diseases, and reduced lifespan

V., & de Castro, H

Due to the risk of Type I error, small subgroup sizes, and substantial heterogeneity, the results should be interpreted cautiously and require confirmation in future well-designed studies

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2) acetoacetate is further activated to acetoacetyl-CoA by 3-ketozcid CoA transferase 1 (SCOT1)