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Palmarosa essential oil (PRO) from Cymbopogon martinii is complementary and conventional medicine worldwide

Mutations within the switch-II pocketincluding Y96C/D/H/N, H95D/G/N/R and R68Sdirectly disrupt drug binding and reduce inhibitor affinity, restoring KRAS activity despite covalent blockade.88 89 Gene amplification of KRAS-G12C increases the total pool of KRAS protein available, saturating inhibitor binding capacity

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