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Unlike immune checkpoint inhibitors, such as PD-1/PD-L1 blockers, which mainly enhance T cell function, Mn + can directly reprogram the tumor microenvironment (TME) by promoting the maturation and differentiation of tumor-associated dendritic cells (DCs) and stimulating substantial production of type I interferon, thereby enhancing the infiltration of CD8 + T cells into tumors [20,21,22]

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Six L68QhCC human carriers taking oral NAC had skin biopsies obtained to determine if hCC deposits were reduced following NAC treatment

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