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Lysophosphatidic acid (LPA) is the simplest phospholipid found in nature, not only it can adjust skin function, hair follicle development, wound healing, and skin itching, but also it can play an important role in scleroderma and skin cancer (94)

Regarding the point, it is well-established that one of the most common complications seen in IBD patients is iron deficiency anemia (IDA) [601]

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Erythroblastic islands-associated tissue-resident ferritin-enriched macrophages perform a function of erythroblast nurse cells, supporting their survival and maturation, providing iron supply for hemoglobin synthesis, promoting proliferation via secreting erythropoiesis-enhancing factors such as IGF-1 and IL-18, and ensuring elimination of phosphatidylserine-exposing pyrenocytes, which represent the extruded nuclei formed within the enucleation process [47,48,49]

Malaguarnera M, Bella R, Vacante M, Giordano M, Malaguarnera G, Gargante MP, et al