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The stratum corneum the outermost layer of skin is specifically designed to keep large molecules out

Sampson CM, Dimet AL, Neelakantan H, Ogunseye KO, Stevenson HL, Hommel JD, Watowich SJ (2021) Combined nicotinamide N -methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice